An evolutionary gap in primate default mode network organization

Clément M Garin; Yuki Hori; Stefan Everling; Christopher T Whitlow; Finnegan J Calabro; Beatriz Luna; Mathilda Froesel; Maëva Gacoin; Suliann Ben Hamed; Marc Dhenain; Christos Constantinidis

doi:10.1016/j.celrep.2022.110669

An evolutionary gap in primate default mode network organization

Cell Rep. 2022 Apr 12;39(2):110669. doi: 10.1016/j.celrep.2022.110669.

Authors

Affiliations

¹ Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, 92265 Fontenay-aux-Roses, France; Université Paris-Saclay, CEA, Molecular Imaging Research Center, 92265 Fontenay-aux-Roses, France. Electronic address: clement.garin@vanderbilt.edu.
² Centre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, London, ON N6A 5B7, Canada.
³ Centre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, London, ON N6A 5B7, Canada; Department of Physiology and Pharmacology, The University of Western Ontario, London, ON N6A 5C1, Canada.
⁴ Department of Radiology, Section of Neuroradiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
⁵ Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
⁶ Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
⁷ Institut des Sciences Cognitives Marc Jeannerod, UMR5229 CNRS Université de Lyon, 67 Boulevard Pinel, 69675 Bron Cedex, France.
⁸ Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, 92265 Fontenay-aux-Roses, France; Université Paris-Saclay, CEA, Molecular Imaging Research Center, 92265 Fontenay-aux-Roses, France.
⁹ Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Neuroscience Program, Vanderbilt University, Nashville, TN 37235, USA; Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: christos.constantinidis.1@vanderbilt.edu.

Abstract

The human default mode network (DMN) is engaged at rest and in cognitive states such as self-directed thoughts. Interconnected homologous cortical areas in primates constitute a network considered as the equivalent. Here, based on a cross-species comparison of the DMN between humans and non-hominoid primates (macaques, marmosets, and mouse lemurs), we report major dissimilarities in connectivity profiles. Most importantly, the medial prefrontal cortex (mPFC) of non-hominoid primates is poorly engaged with the posterior cingulate cortex (PCC), though strong correlated activity between the human PCC and the mPFC is a key feature of the human DMN. Instead, a fronto-temporal resting-state network involving the mPFC was detected consistently across non-hominoid primate species. These common functional features shared between non-hominoid primates but not with humans suggest a substantial gap in the organization of the primate's DMN and its associated cognitive functions.

Keywords: BOLD; CP: Neuroscience; DMN; evolution; fMRI; macaque; marmoset; medial prefrontal cortex; mouse lemur; primates; resting-state.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Brain Mapping*
Brain*
Callithrix
Default Mode Network
Magnetic Resonance Imaging
Neural Pathways

Abstract

Publication types

MeSH terms

Grants and funding